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Reference Architecture for Workloads using Lenovo ThinkAgile HX and FX Series

Reference Architecture

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Updated
26 Dec 2025
Form Number
LP0665
PDF size
139 pages, 12.2 MB

Abstract

This document describes the reference architecture (RA) for different workloads using the Lenovo ThinkAgile HX Series and FX Series appliances and certified nodes. The intended audience for this document is technical IT architects, system administrators, and managers who are interested in executing virtualization, container and AI/ML workloads on these hyperconverged servers.

The RA provides a technical overview of the appliances and explains why the combination of Lenovo servers and Nutanix software provides best of breed system performance and reliability. The RA contains one chapter per workload which describes the workload components, server configurations, performance and sizing recommendations, and deployment best practices.

Table of Contents

1. Introduction
2. Technical overview of appliances
3. Deployment Models
4. Citrix Virtual Apps and Desktops
5. Microsoft SQL Server
6. Red Hat OpenShift Container Platform
7. Omnissa Horizon
8. Veeam Backup with ThinkSystem DE/DM/DG
9. Nutanix Cloud Platform
10. Hybrid backup with AWS
11. Enterprise AI with NVIDIA

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Tip: For SAP applications, see the document Reference Architecture for SAP Applications using Lenovo ThinkAgile HX Series, https://lenovopress.com/lp1413

Change History

Changes in the December 26, 2025 update:

  • Section 2.1 Removed withdrawn models and Updated with ThinkAgile HX V3 and HX V4 systems
  • Section 2.2 Added ThinkAgile FX series
  • Section 2.3 Updated with Lenovo XClarity One and Nutanix Prism Central
  • Section 3 Updated deployment models with HX V4 and FX V4 series (Intel Xeon 6 processors and AMD EPYC 9005 processors)
  • Section 3.1.3 and 8 Removed VMware vCloud Suite workload
  • Section 3.1.3 Added deployment model for Nutanix Cloud platform
  • Section 4.6 Removed benchmark results for withdrawn models. Added Login Enterprise Results on AHV with AMD EPYC 9005 Processors
  • Section 6 Updated configuration with Intel Xeon 6 Processors and HX V4 servers
  • Section 7 Updated VMware with Omnissa Horizon. Removed withdrawn HX models and respective benchmark results. Updated sizing with HX V4 systems with Intel Xeon 6 Processors
  • Section 9 Updated Nutanix Cloud Platform with deployment steps and BOM with Intel Xeon 6 processors and AMD EPYC 9005 processors
  • Section 11 Updated Nutanix Enterprise AI with ThinkAgile HX V4 with Intel Xeon 6 processors and HX V3 AMD EPYC 9005 processors